A recent meta-analysis shows that a Vitamin D deficiency may be a risk factor for developing TB not something caused by the disease.
More than one study has linked TB and a Vitamin D deficiency (VDD). Researchers looked at 38 studies. In 25 of these studies almost 3,600 patients were TB cases and over 3,000 were control subjects. The results of the review showed that Vitamin D levels were significantly lower in TB patients when compared to the control groups and VDD was associated with an increased risk of TB.
Over 220 TB patients from 3 studies receiving up to four months of anti-TB treatments and 4 studies with over 390 TB patients who received the full anti-TB treatment course showed that the anti-TB treatment did not have an effect on Vitamin D levels. Also an additional four studies with over 300 TB cases after anti-TB treatment completion and over 590 control subjects who did not have TB showed that patients Vitamin D levels were still significantly lower than the control subjects after the completion of their anti-TB treatments.
Researchers concluded that more studies would be needed to determine whether Vitamin D Supplementation was actually beneficial to TB treatment as well as TB prevention.
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