Selenium May Protect Against Epileptic Seizures, Mouse Study Suggests

Selenium and Epileptic SeizuresA new study finds the presence of Selenium in an enzyme involved in fighting oxidative stress may be necessary in preventing epileptic seizures.  The anti-oxidative enzyme, Glutathione peroxidase 4 (GPX4) normally contains Selenium in the form selenocysteine, an amino acid.  Mice that were missing Selenium in this GPX4 enzyme did not develop specialized brain cells (paravalbumin interneurons) and as a result suffered epileptic seizures that were fatal within three weeks.

Researchers found that the protein selenocysteine needs to be found in the enzyme GPX4 and is critical for providing the anti-oxidative protection of the interneurons.  As shown in prior studies, the paravalbumin interneurons play a role in regulating excitability in the cortex of the brain.  This neuronal hyperexcitability is associated with epilepsy.

Researchers believe when translated to humans, the study shows Selenium plays a vital role in post-natal brain development and may be important since neurons themselves contain high amounts of polyunsaturated fatty acid (PUFAs) which are needed for synapse formation as well as migration.  This makes these neurons vulnerable to cell death (ferroptosis).

Further studies are recommended.

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I have been involved in the Wellness Industry for over 25 years. I am a Certified Dietary Supplement Specialist and regularly lectures at various higher learning institutions on basic vitamin/mineral/herbal supplement facts. I became involved in the industry after being diagnosed with chronic fatigue syndrome. Not satisfied with conventional treatment methods, I began to learn about natural remedies and slowly began to see changes in my condition. Driven by my own results with natural products I developed a passion to pass on those same benefits to others who also suffered any number of ailments and wanted a natural treatment alternative that offered results. In store, myself and my highly trained staff of vitamin specialists offer free consultations and vitamin fitting options that create lifestyle programs that customers can live and thrive with for noticeable benefits. By doing extensive research about quality the store is able to cut the guess work out for out customers. Instead of offering a multitude of different brand alternatives, we only offer the highest quality products that way insuring optimal results for the customer. The store’s fundamental philosophy focuses on integrity selling and results. Please feel free to call on us to answer all of your vitamin and nutritional needs.

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