Antioxidants Might Help in Early Diabetic Kidney Disease

Antioxidants and Kidney DiseaseA recent meta-analysis and review found supplementation with antioxidants, like Vitamin E, may reduce the loss of a specific protein, albumin, in a patient’s urine.  The excretion of albumin is an early sign of diabetic kidney disease (DKD).

The purpose of the meta-analysis and review was to determine if antioxidant supplementation would slow the progression of DKD to end state kidney disease (ESKD).  DKD is the prime cause of ESKD.  Approximately half of all long-term diabetics end up developing some form of kidney damage over their lifetime.  Most trials reviewed used Vitamin E and or Vitamin E as well as B6, Zinc, Alpha Lipoic Acid, Silymarin and reduced Glutathione.  Antioxidants were used either individually or in combination.

Most antioxidants showed some benefit in reducing Urinary Albumin Excretion (UAE).  Vitamin E showed the most consistent benefit.  Researchers found it difficult to reach any strong conclusions due to the diversity in study designs, trial sizes, outcome measures to name a few of the meta-analysis challenges.  However researchers did find a benefit of antioxidant therapy (especially Vitamin E) on early signs of renal damage.

Further studies are needed.

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High-Dose Vitamin C Could Cut Duration of Common Cold (and Other Infections)

A new review of prior clinical data shows high doses of Vitamin C might reduce the duration of common colds and other types of infections.  At a dose rate of between 6 to 8 grams of Vitamin C, prior studies show the duration of colds reduced by almost 20%.

In one study 3 grams of Vitamin C per day was given to 2 participating groups a third group was given a Vitamin C dose of 6 grams per day and a fourth group received a placebo.  When compared to the placebo group the group receiving the 6 grams of Vitamin C daily experienced a 17% reduction in the duration of their colds.  This result was twice as much as the group receiving the 3 grams of Vitamin C per day.

In another study one group received a Vitamin C dose of 4 grams per day while another group supplemented 8 grams of Vitamin C daily while others additional groups received a placebo.  These dosages of Vitamin C and the placebo were administered on the first day of the cold.  The results showed that when compared to the group supplementing with the placebo the participants supplementing with the 8 grams of daily Vitamin C showed there colds were shortened by about 19% which was twice as much as the group supplementing with the 4 grams of daily Vitamin C.

Researchers suggested that the majority of prior controlled studies used a dose of only 1 gram of Vitamin C daily and that when looking at studies using a wider range of dosages as outlined above it may explain why lower dosage studies found no correlation between Vitamin C and reduced durations of cold and other infections. Researchers suggest that new randomized trials using higher dosages of Vitamin C must be performed.

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CoQ10 Supplementation Shows Benefits for Liver Cancer Patients Post Surgery

liver cancerA new study shows daily supplementation with 300 mg of CoQ10 significantly increases antioxidant capacity and reduces inflammation levels and oxidative stress levels after surgery for patients with hepatocellular carcinoma (HCC), the most common type of liver cancer.

41 patients with hepatocellular carcinoma (HCC) participated in this single-blinded, randomized, parallel, placebo-controlled study.  A random numbers table was used to randomly assign the participants to receive either the CoQ10 (300 mg) or a placebo.  The study lasted 12 weeks.  The levels of antioxidant enzymes activity was significantly increased in the CoQ10 supplement group.  Additionally the CoQ10 group had significantly decreased oxidative stress and inflammatory markers levels when compared to the placebo group.

Larger and longer studies are needed to confirm the benefits seen with CoQ10 supplementation in patients with HCC taken after surgery.

CoQ 10 is a cell oxygenator and supports the transfer of oxygen between the cells. It is an antioxidant and supports cardiovascular health by promoting energy on a cellular level. Scientific studies show Co Q 10 is three times more bioavailable when delivered in an oil based softgel capsule.

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Vitamin C and E Supplements May Protect Against Age-Related Brain Declines

Cognitive DeclineData from a recent study shows daily supplementation with Vitamin C and Vitamin E could reduce the risk of cognitive decline.

Data from over 5,000 seniors collected over a period of time (from 1991-2002) was analyzed.  Participants were all over 65 years of age.  Seniors who were supplementing with Vitamin E and/or Vitamin C had a statistically significant 40% reduction in all cause-dementia and a 42% reduction in Alzheimer’s disease (AD).  Compared to non vitamin users, participants who were supplementing with either Vitamin C or Vitamin E separately saw a 43% and 46% reduction in the risks of developing Alzheimer’s disease.  Additionally, the risk of developing cognitive impairment not dementia (CIND), were reduced by 31% in the seniors who supplemented with Vitamin C and 32% for seniors who supplemented with Vitamin E.

As we age there is a natural decline in brain function.  Mild cognitive impairment is considered a transitional state and small changes in mental abilities and memory coexist with normal functioning.  These declines in functions may often be a warning sign of dementia.  Dementia is a term that is used to describe many different brain disorders that all share a progressive loss of brain function.  It is believed that Oxidative stress may be a contributing factor to this process.

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Resveratrol Shows Metabolic and Brain Signaling Benefits

ResveratrolA new animal study found that daily supplementation with Resveratrol may increase energy metabolism, cell signaling pathways and neurotransmission.

23 male adult monkeys were randomly assigned to one of three groups: A control group fed a healthy diet, A negative control group fed a diet high in sugar and fat and a group fed a diet high in sugar and fats and supplemental Resveratrol (80 mg per day for the first year and 480 mg per day for the second year).  The study lasted 2 years.  Researchers used proteomics to identify changes in the expression of 12 specific proteins in the brains of these rhesus monkeys.

Improvements in energy metabolism and the efficiency of cell signaling pathways and neurotransmission in the group supplementing with the Resveratrol in addition to the high fat and sugar diet were seen.

This study adds to the existing science on the healthy benefits of Resveratrol, a very powerful polyphenal.  A lot of research has focused on Resveratrol’s cardiovascular benefits due to the nutraceuticals association with the “French Paradox”.  This phrase was used to describe the low incidence of obesity and heart disease in the French people even though they have a diet moderately high in fat.  It is believed to be their consumption of Red wine that neutralizes the damage of their high fat diet.

Further studies are needed.

A good Resveratrol product will be standardized to 200 mg of trans-resveratrol (the phyto-nutrient in the resveratrol that gives the polyphenal its beneficial properties).  Additional Grape Seed Extract may be added to provide additional antioxidant benefits.

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CoQ10 May Help Blood Sugar Management in People with Metabolic Syndrome

Metabolic SyndromAccording to a new study daily CoEnzyme Q10 supplementation may produce a beneficial effect on blood sugar management and insulin in people with metabolic syndrome.

60 individuals with metabolic syndrome were randomly assigned to receive either a placebo or 100 mg of CoQ10 daily.  The study lasted 8 weeks.  Participants ranged in age from 40 to 85.  Individuals in the CoQ10 group saw significant improvements in insulin resistance as measured using the homeostatic model assessment HOMA-IR, serum insulin levels and beta-cell function measured using the homeostatic model assessment beta cell function HOMA-B.  Reductions in markers for oxidative stress and improvements in glutathione levels were also observed.  No changes however, were observed for fasting blood sugar levels, markers of inflammation or cholesterol levels.

CoQ10 is a cell oxygenator and aids in the transport of energy from cell to cell.  This keeps the body in an aerobic state of metabolism and provides a strong antioxidant benefit.

Metabolic syndrome (MetS) is a condition characterized by obesity, disturbed glucose and insulin metabolism and hypertension.  Metabolic Syndrome is also believed to increase the risks of developing cardiovascular disease and type 2 Diabetes.

When searching out a CoEnzyme Q10 product make sure the product is processed through a natural fermentation process and is not synthetic.  Also make sure the product is the trans form of the CoQ10 which is the most active form and that the product contains no cis-isomers.

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Lycopene, Lutein Supplements Show Skin Protection From Within Against UV Radiation

UV ProtectionA new study has found supplementing lutein or lycopene, a rich tomato nutrient, may protect against the damage of UV skin exposure.  The findings of the study show oral supplementation with either of these carotenoids may change the expression of genes that are indicators of photo-aging, pho-dermatoses and oxidative stress.

65 participants between the ages of 18 and 60 volunteered for this double blinded, randomized cross-over study.  The participants were randomly assigned to supplement 20 mg of lutein, 20 mg of a tomato nutrient complex or a placebo.  The study lasted 24 weeks with a 2 week wash out period separating the placebo and an active intervention period.  The skin was irradiated at the beginning and at the end of each phase of the study.  The Lutein only group showed that gene expression was completely inhibited if the Lutein was taken during the first 12 weeks (ie prior to the placebo) and a significantly smaller effect was seen if the Lutein was taken during the second 12 week phase (ie after the placebo).  The tomato nutrient complex group saw the up regulation of HO-1, ICAM-1 and MMP1 mRNA by both UVA1 and UVA/B were totally inhibited.

Although the exact way that lutein and lycopene inhibit UVA1 radiation induced gene expression is not actually known, researchers believe it involves the anti-oxidative role that these carotenoids play.

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