Low Vitamin D May Be Linked To Fertility And Miscarriage Risk-Especially After Prior Pregnancy Loss

Vitamin D and Miscarriages-FertilityResearchers have found that women who have sufficient levels of Vitamin D may be more likely to become pregnant and have a live birth when compared to women whose Vitamin D levels are considered to be insufficient.

Data collected as part of the Effects of Aspirin in Gestation and Reproduction (EAGer) study was analyzed.  This study looked at women who had a history of pregnancy loss to find if an 81 mg dose of aspirin (low-dose) taken daily could prevent a miscarriage. Over 1200 women participated in this study.  Blood levels of Vitamin D were tested both before pregnancy and at the eighth week of pregnancy.  Vitamin D levels below 30 nanograms per milliliter were considered to be insufficient for research.

Women whose preconception Vitamin D concentrations were considered to be sufficient were 10% more likely to achieve pregnancy and 15% more likely to have a live birth when compared with the women’s whose preconception Vitamin D concentrations were considered to be insufficient.  In the women who become pregnant researchers determined that for each 10 nanogram per milliliter increase in Vitamin D concentrations prior to conception there was a 12% reduction in the risk of pregnancy loss.

Because the result of these findings were determined in a secondary analysis, proving any cause and effect between insufficient Vitamin D levels and Miscarriage risks solely based on these results are impossible, however further studies are now necessary according to the researchers.

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Could Vitamin D Help Women Undergoing Fertility Treatment?

Vitamin D and FertilityA new meta-analysis and review appearing in Human Reproduction found higher Vitamin D levels were associated with better birth rates in women receiving fertility treatment.

11 studies with over 2,700 women undergoing fertility treatment, frozen embryo transfer, in vitro fertilization (IVF), and/or intracytoplasmic sperm injection (ICSI) were reviewed.  Participants Vitamin D status was measured by means of blood tests.  75 nanomoles per liter (nmol/L) was considered to be a sufficient Vitamin D status while 50 nmol/L was considered to be deficient. Vitamin D status between those 2 defined limits was considered as insufficient.

Results showed a high amount of Vitamin D deficiency among the study participants with only 26% of women participating in these studies having sufficient serum Vitamin D levels. Additionally 35% of participants had deficient levels of Vitamin D and 45% had insufficient Vitamin D levels.  Researchers also found that women with adequate Vitamin D levels had a 33% higher likelihood of having a live birth when compared with participants whose Vitamin D status was either insufficient or deficient.  Additionally other conception related outcomes were improved in participants with sufficient Vitamin D levels. Women achieving a positive pregnancy test two weeks after an embryo transfer were 34% higher in women with sufficient Vitamin D status when compared with participants with either insufficient or deficient Vitamin D levels.  In studies measuring the presence of a fetal heart beat at 5 weeks after an embryo transfer (“Clinical Pregnancy”), a 46% improvement in outcome was seen in participants considered to have sufficient Vitamin D levels.

Researchers stressed that although no causal connection could be attributed to Vitamin D and pregnancy outcomes, treating Vitamin D deficiency and insufficiency could be essential to women undergoing fertility treatment.  Additionally researchers believe a randomized controlled trial is needed to investigate the benefits of Vitamin D deficiency and fertility treatment outcomes.

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Study Underscores Positive Effect of Vitamin D on Female Fertility

Vitamin D and Female FertilityNew research linking Vitamin D levels to regulation of ovarian hormones shows Vitamin D status may play an essential role in female reproduction and fertility.

49 women, ages 19 through 25, participated in this study.  The criteria for women to participate in this research were as follows:

Participants must have regular menstrual cycles

Participants could not be pregnant

Participants had not breastfed within the past two months

Participants had not supplemented with Vitamin D

Participants had not travelled to the northern hemisphere

Participants had not used a tanning booth or sunbed

Participants were given a Vitamin D supplement or a placebo during the week after their menstrual period began.  Changes in AMH levels (anti-Mullerian hormone levels) were analyzed. The anti-Mullerian hormone is an ovarian regulator however; its function is largely unknown.  Results of the study showed a single dose of oral Vitamin D generated a sharp change in the serum levels of 25(OH)D (the most accurate measure of Vitamin D in the body).  A progressive rise in the participants AMH levels was also seen.  These findings support the theory the Vitamin D has a positive effect on a women’s fertility and may involve the regulation of AMH levels.

Researchers strongly suggest further clinical studies are needed.

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