Could Probiotics Restore Microbiome Imbalance Linked to Auto-Immune Disorder?

Probiotics and ImmuneA new study finds that probiotics may aid in restoring imbalances in gut bacterial in patients with the auto-immune disorder systemic sclerosis.  Systemic sclerosis affects connective tissue in the body.  It is not a common condition, but results in the skin thickening and becoming hard.  Occasionally this condition creates problems with blood vessels and internal organs.

17 adults with systemic sclerosis from UCLA, 17 adults with systemic sclerosis from Oslo University Hospital and 17 healthy adults participated in this trial.  Stool specimens were used to determine the amount and types of bacteria present.  Participants with systemic sclerosis had significantly lower amounts of gut bacteria believed to protect against inflammation like Bacteroides.  Additionally the participants with systemic sclerosis were found to have higher amounts of bacteria, like Fusobacterium, which actually promote inflammation when compared to those without this auto-immune disorder.

Researchers believe that probiotics are helpful in restoring the bacterial balance in the gut in individuals suffering from systemic sclerosis and play a role in improving these patients quality of life.

Further testing is planned using larger patient groups.

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High-Dose Vitamin C Could Cut Duration of Common Cold (and Other Infections)

A new review of prior clinical data shows high doses of Vitamin C might reduce the duration of common colds and other types of infections.  At a dose rate of between 6 to 8 grams of Vitamin C, prior studies show the duration of colds reduced by almost 20%.

In one study 3 grams of Vitamin C per day was given to 2 participating groups a third group was given a Vitamin C dose of 6 grams per day and a fourth group received a placebo.  When compared to the placebo group the group receiving the 6 grams of Vitamin C daily experienced a 17% reduction in the duration of their colds.  This result was twice as much as the group receiving the 3 grams of Vitamin C per day.

In another study one group received a Vitamin C dose of 4 grams per day while another group supplemented 8 grams of Vitamin C daily while others additional groups received a placebo.  These dosages of Vitamin C and the placebo were administered on the first day of the cold.  The results showed that when compared to the group supplementing with the placebo the participants supplementing with the 8 grams of daily Vitamin C showed there colds were shortened by about 19% which was twice as much as the group supplementing with the 4 grams of daily Vitamin C.

Researchers suggested that the majority of prior controlled studies used a dose of only 1 gram of Vitamin C daily and that when looking at studies using a wider range of dosages as outlined above it may explain why lower dosage studies found no correlation between Vitamin C and reduced durations of cold and other infections. Researchers suggest that new randomized trials using higher dosages of Vitamin C must be performed.

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CoQ10 Supplementation Shows Benefits for Liver Cancer Patients Post Surgery

liver cancerA new study shows daily supplementation with 300 mg of CoQ10 significantly increases antioxidant capacity and reduces inflammation levels and oxidative stress levels after surgery for patients with hepatocellular carcinoma (HCC), the most common type of liver cancer.

41 patients with hepatocellular carcinoma (HCC) participated in this single-blinded, randomized, parallel, placebo-controlled study.  A random numbers table was used to randomly assign the participants to receive either the CoQ10 (300 mg) or a placebo.  The study lasted 12 weeks.  The levels of antioxidant enzymes activity was significantly increased in the CoQ10 supplement group.  Additionally the CoQ10 group had significantly decreased oxidative stress and inflammatory markers levels when compared to the placebo group.

Larger and longer studies are needed to confirm the benefits seen with CoQ10 supplementation in patients with HCC taken after surgery.

CoQ 10 is a cell oxygenator and supports the transfer of oxygen between the cells. It is an antioxidant and supports cardiovascular health by promoting energy on a cellular level. Scientific studies show Co Q 10 is three times more bioavailable when delivered in an oil based softgel capsule.

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Heightened Liver Cancer Risk Linked to Low Selenium Levels

SeleniumA recent study found an increased risk of developing cancer of the liver may be linked with low levels of the trace mineral selenium.  Western diets and lifestyles were blamed for this selenium deficiency.

Data from the EPIC cohort study was analyzed to provide data for this study.  Over 500,000 men and women between the ages of 25 and 70 participated in the EPIC cohort study between the years 1992 and 2000.  Study participants filled out questionnaires regarding lifestyle information like activity levels, medical and smoking histories and education.  Blood levels of selenium were also collected.  A control group was established by utilizing data from 121 individuals with liver cancer and 140 individuals with biliary tract and bladder cancer.  Equal numbers of individuals who were cancer free were matched against the first group.

Observational and experimental evidence found low intakes of the trace mineral selenium contributed to the development of many cancers.  Selenium is known to protect cells from oxidative stress and this role may account for the outcome of this study.

A growing body of data shows increasing rates of liver cancer in industrialized countries due to unhealthy lifestyle and dietary habits.  Treatment options may be limited since liver cancers are usually diagnosed at later stages.

Further research is planned.

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