A recent meta-analysis and review found supplementation with antioxidants, like Vitamin E, may reduce the loss of a specific protein, albumin, in a patient’s urine. The excretion of albumin is an early sign of diabetic kidney disease (DKD).
The purpose of the meta-analysis and review was to determine if antioxidant supplementation would slow the progression of DKD to end state kidney disease (ESKD). DKD is the prime cause of ESKD. Approximately half of all long-term diabetics end up developing some form of kidney damage over their lifetime. Most trials reviewed used Vitamin E and or Vitamin E as well as B6, Zinc, Alpha Lipoic Acid, Silymarin and reduced Glutathione. Antioxidants were used either individually or in combination.
Most antioxidants showed some benefit in reducing Urinary Albumin Excretion (UAE). Vitamin E showed the most consistent benefit. Researchers found it difficult to reach any strong conclusions due to the diversity in study designs, trial sizes, outcome measures to name a few of the meta-analysis challenges. However researchers did find a benefit of antioxidant therapy (especially Vitamin E) on early signs of renal damage.
Further studies are needed.
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