Could Vitamin D Help Women Undergoing Fertility Treatment?

Vitamin D and FertilityA new meta-analysis and review appearing in Human Reproduction found higher Vitamin D levels were associated with better birth rates in women receiving fertility treatment.

11 studies with over 2,700 women undergoing fertility treatment, frozen embryo transfer, in vitro fertilization (IVF), and/or intracytoplasmic sperm injection (ICSI) were reviewed.  Participants Vitamin D status was measured by means of blood tests.  75 nanomoles per liter (nmol/L) was considered to be a sufficient Vitamin D status while 50 nmol/L was considered to be deficient. Vitamin D status between those 2 defined limits was considered as insufficient.

Results showed a high amount of Vitamin D deficiency among the study participants with only 26% of women participating in these studies having sufficient serum Vitamin D levels. Additionally 35% of participants had deficient levels of Vitamin D and 45% had insufficient Vitamin D levels.  Researchers also found that women with adequate Vitamin D levels had a 33% higher likelihood of having a live birth when compared with participants whose Vitamin D status was either insufficient or deficient.  Additionally other conception related outcomes were improved in participants with sufficient Vitamin D levels. Women achieving a positive pregnancy test two weeks after an embryo transfer were 34% higher in women with sufficient Vitamin D status when compared with participants with either insufficient or deficient Vitamin D levels.  In studies measuring the presence of a fetal heart beat at 5 weeks after an embryo transfer (“Clinical Pregnancy”), a 46% improvement in outcome was seen in participants considered to have sufficient Vitamin D levels.

Researchers stressed that although no causal connection could be attributed to Vitamin D and pregnancy outcomes, treating Vitamin D deficiency and insufficiency could be essential to women undergoing fertility treatment.  Additionally researchers believe a randomized controlled trial is needed to investigate the benefits of Vitamin D deficiency and fertility treatment outcomes.

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Could Curcumin Benefit Gut Diversity and Prevent Post-Menopausal Weight Gain?

Curcumin and Weight GainAccording to a new study on rats, Curcumin may aid in reversing decreases in the diversity of gut bacteria after an ovariectomy (OVX) which may prevent weight gain often seen in post-menopausal women.

The study lasted 12 weeks.  Rats were split into three groups: rats having undergone an ovariectomy and fed distilled water (OVX); a control group of rats who underwent a sham operation (SHAM); rats having undergone an ovariectomy and given Curcumin (CUR).  The OVX group showed reduced gut bacterial diversity when compared with the SHAM group.  The CUR group however, displayed significantly different amounts of seven bacterial strains when compared with the OVX group.  Rats in the OVX group also showed a significant weight gain when compared to the control group (SHAM).  The CUR Group however, did not experience this weight gain.  No estrogenic effects were seen in the group supplementing with the Curcumin (CUR) since it did not prevent reductions in serum estradiol levels or uterine weight loss.

OVX rats showed a higher ratio of phyla Firmicutes and Bacteroidetes in the gut when compared with the control group.  These specific bacterial strains have been observed to lead to overweight rats and have also been associated with obesity in humans.  An additional benefit of Curcumin supplementation was a reduction in the bacteria Anaerotruncus, which has been associated with age-related macular degeneration and pre-natal stress.  Researchers also found Curcumin reduced the amount of Helicobacter pylori or H. pylori, the bacteria responsible for certain stomach ulcers.

Curcumin is the phyto nutrient found in turmeric.  It is a powerful antioxidant and has been show to support cardiovascular health as well as joint health in addition to a host of other promising impactful health promoting mechanisms.

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Recent RCT Discovers Vitamin D Deficiency May Double the Risk of Preeclampsia in Pregnant Women

Vitamin D and Pre-EclampsiaA new study finds that gestational hypertension/preeclampsia could be reduced with Vitamin D supplementation therapy.

Over 140 women with a history of preeclampsia participated in this study.  Women with hypertension before their pregnancy, a history of pulmonary, renal or cardiac disease and Vitamin D levels above 25 ng/ml (optimal Vitamin D levels are considered to be between 40 – 60 ng/ml) were excluded from the trial.    Vitamin D levels were taken at baseline.  70 of the participants (the intervention group) received a 50,000 IU Vitamin D supplement every two weeks.  The remaining participants (the control group) received a placebo.  The study lasted until the 36th week of pregnancy.  The control group experienced a 1.94 times increase in the risk of developing preeclampsia when compared to the intervention group.

Preeclampsia is a form of high blood pressure (hypertension) related to pregnancy and is characterized by excess protein in the urine and high blood pressure.  This condition is fairly easy to treat but can be very harmful to both the child and the mother and accounts for approximately 25% of all maternal deaths.  Preeclampsia also increases the risk the baby will be born prematurely or small for their gestational age with increases the risk of infant mortality.

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Study Supports Efficacy of Hyaluronic Acid for Wrinkle Reduction

Hyaluronic Acid and Wrinkle ReductionA new study shows supplementing with Hyaluronic Acid for twelve weeks may reduce wrinkles and improves the luster of the skin.

60 adults participated in this randomized, double-blind, placebo-controlled trial.  Participants ranged in age from 22 to 59 years of age and included both men and women.  Individuals were randomly chosen to be in 1 of 3 groups.  The first group received a placebo; the next group received a Hyaluronic Acid (HA) formulation with a molecular weight of 2k.  The last group received an HA supplement with a molecular weight of 300k.  The groups receiving the HA received a dosage of 120 mg daily.

Using three-dimensional analysis of the participants skin, researchers found that the groups supplementing with the HA had a better level of the whole sulcus (groves in the skin) to volume ratio, wrinkle volume ration and wrinkle area ration.  The Hyaluronic Acid group supplementing with the product with the 300k molecular weight also saw significant reductions in wrinkles when compared with the group supplementing with the placebo.

50% of the body’s Hyaluronic Acid is found in the skin.  Breakdowns of collagen and Hyaluronic Acid are believed to be the cause of wrinkles.  Because Hyaluronic Acid effects the skin cells it is noted that daily supplementation with HA can moisturize the skin since the metabolites of HA increase the skin moisture content.

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Study Underscores Positive Effect of Vitamin D on Female Fertility

Vitamin D and Female FertilityNew research linking Vitamin D levels to regulation of ovarian hormones shows Vitamin D status may play an essential role in female reproduction and fertility.

49 women, ages 19 through 25, participated in this study.  The criteria for women to participate in this research were as follows:

Participants must have regular menstrual cycles

Participants could not be pregnant

Participants had not breastfed within the past two months

Participants had not supplemented with Vitamin D

Participants had not travelled to the northern hemisphere

Participants had not used a tanning booth or sunbed

Participants were given a Vitamin D supplement or a placebo during the week after their menstrual period began.  Changes in AMH levels (anti-Mullerian hormone levels) were analyzed. The anti-Mullerian hormone is an ovarian regulator however; its function is largely unknown.  Results of the study showed a single dose of oral Vitamin D generated a sharp change in the serum levels of 25(OH)D (the most accurate measure of Vitamin D in the body).  A progressive rise in the participants AMH levels was also seen.  These findings support the theory the Vitamin D has a positive effect on a women’s fertility and may involve the regulation of AMH levels.

Researchers strongly suggest further clinical studies are needed.

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Vitamin D and Calcium May Reduce Onset of Early Menopause

Calcium Vitamin D Early MenopauseA new study shows a reduction in the risk of early menopause when high doses of dietary Vitamin D and Calcium are taken.  Early menopause is associated with higher risks for Osteoporosis, Early Cognitive Decline, Cardiovascular Disease and other health issues.

Over 116,000 female US registered nurses participated in this study.  Individuals between the ages of 25 and 42 in 1989 participated in this study and responded to a questionnaire.  Intakes of Vitamin D and Calcium from both supplements and food were measured every four years and medical conditions and behaviors were measured every two years. Over 2000 women reported having natural menopause before 45 years of age.  Incidents of possible confounding factors were accounted for when evaluating the relationship between the intake of Calcium and Vitamin D and incidents of early menopause.

A 17% lower risk of early menopause was seen in the women who had the highest intake of Vitamin D when compared with the women who had the lowest intake of Vitamin D.  A “borderline significantly lower risk” of early menopause was seen in the women with the highest intake of Calcium when compared to the women with the lowest intake of Calcium.

Further studies are now being undertaken.

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Vitamin B’s Women’s Benefits: Supplementation Boosts Convention Yeast Infection Treatment RCT Finds

B VitaminsAccording to a new study supplementing with Vitamin B along with doing the conventional treatment can help treat complicated cases of vulvovaginal candidiasis (VVC).  VVC is a fungal infection caused by the Candida species, the second major cause of vaginitis in women, with the first major cause being bacterial vaginitis.  75% of women are infected with VVC at least once in their life prior to menopause.  5% of these women experience VVC on a recurrent basis.

Over 150 women with VVC participated in this study and were randomly assigned into groups as follows: Group A (received a suppository and oral antifungal) Group B (received a suppository and a vaginal cream) and Group C (received a suppository, vaginal cream and a Vitamin B Complex supplement).  Patients in Group C (92.73%) saw a significantly higher rate of treatment success, percentage of patients with recovery, marked effective and improvement, in comparison to Groups A (73.47%) and B (79.63%).  The recovery rate alone was also higher in Group C (72.73%) compared with Group A (61.22%) and Group B (62.96%).

Researchers concluded the Supplementing with Vitamin B Complex might be an effective additional therapy for treating complicated VVC.

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