Lutein Levels Linked To A More Agile And “Youthful” Brain

Lutein and CognitionA new study finds a high intake of Lutein may slow down cognitive decline.

60 healthy adults between the ages of 25 and 45 participated in this study.  Carotenoid levels were assessed by measuring MPOD (Macular Pigment Optical Density), which is considered a trusted indicator of Lutein levels in the brain. Event related brain activity was used as a gauge of cognitive function and was recorded as the participants performed cognitive control testing.  Study results showed MPOD was related to both specific electrical brain activity and age during the decision making process, known as the P3 wave.  Younger adults showed a larger abundance of P3 than the older participants however, the older participants with higher MPOD levels displayed P3 measures equal to the younger participants.  Researchers concluded that Lutein appears to have a protective role in the brain since the study data indicated that participants with more Lutein were able to utilize more cognitive resources to finish their tasks.

Besides being beneficial to brain health, Lutein and Zeaxanthin have been shown to provide support for vision and vision diseases since Lutein appears to accumulate in both the brain and in the eyes.  The ability of Lutein in brain processing, memory, speed and processing is intriguing since Lutein cannot be manufactured on its own in the body.

Further study is warranted.

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Folic Acid and Dementia: Supplementation Benefits Elderly People with Mild Cognitive Decline

Folic Acid and Cognitive ImpairmentElderly people with mild cognitive impairment saw significant improvements in both cognitive performance and reduced inflammation when supplementing with 400 mcg of Folic Acid daily for a period of 12 months.

Over 150 seniors with mild cognitive impairment were randomly assigned to two groups.  One group received daily Folic Acid supplementation (400 mcg) and the other group was a conventional-treatment group.

Significant improvements in cognitive function were seen in the group supplementing with Folic Acid.  Additionally a significant reduction in levels of inflammatory cytokines was seen.  Peripheral inflammatory cytokines appear to be biomarkers for identifying individuals who may be at a greater risk of developing Alzheimer’s disease or dementia. Researchers believe looking at the role of inflammatory markers at the onset of dementia, before full clinical dementia syndrome has developed, is essential.  Researchers concluded that folic acid has significant memory enhancing and anti-inflammatory properties.

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Lutein and Zeaxanthin Levels Linked to Better Cognitive Function

Lutein and Cognitive FunctionA new study has found that higher blood levels of Lutein and Zeaxanthin may be associated with improved memory, cognition and executive function.  Data from this study found higher Zeaxanthin levels were associated with increased processing speeds and higher levels of both Zeaxanthin and Lutein were associated with enriched scores for many cognitive measures.

Data from over 4,000 adults aged 50 and older was analyzed.  Researchers inferred that a good biological basis exists for hypothesizing that Lutein and Zeaxanthin may be neuroprotective due to their anti inflammatory cell signaling properties and due to their antioxidant properties.

A link between eye health and Lutein was established in 1994 when researchers found a link between the consumption of dark leafy vegetables (carotenoid rich foods) and a reduction in the incidence of age-related macular degeneration (AMD).  Additional studies now support the effects Lutein has on brain health.  Studies show that the carotenoids found in pediatric brain tissue is 60% Lutein yet only about 12% of the carotenoids found in the average diet contains Lutein.  Researchers have concluded that the brain has a preference for Lutein.

More studies are definitely needed.

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Vitamin A Status At Birth Linked to Long-Term Risk of Cognitive Impairment and Alzheimer’s

Cognitive FunctionA new study has found elderly individuals with low Vitamin A levels may be more at risk of developing Alzheimer’s disease along with lower brain functioning.  Additionally the study found the even a marginal Vitamin A deficiency at birth might affect long-term risk factors.

This new study was made up of findings from mouse models as well as human population data.  The population study revealed that 75% of those with either a significant or even mild Vitamin A deficiency had some cognitive impairment compared to 47% with normal Vitamin A levels that experienced cognitive impairment.  The research on mice confirmed this finding.  Even a mild Vitamin A deficiency during pregnancy or immediately after birth was associated with an increase in the production of amyloid-beta plaques which are associated with Alzheimer’s disease.  Researchers found that mice deprived of Vitamin A performed poorly on standardized tests of memory as well as learning as adults.  Mice that had Vitamin A withheld while they were in the womb but were given a normal diet after they were born had lower performance in general when compared to mice receiving adequate Vitamin A in the womb but were deprived Vitamin A after birth.  It was found that some reversal of decline could be reversed with adequate Vitamin A supplementation.  Researchers concluded that monitoring Vitamin A during infancy as well as during pregnancy and eliminating a prenatal Vitamin A deficiency may aid in halting Alzheimer’s disease development.

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Omega-3’s Linked to Better Cognitive Function in Mildly Impaired Older People

Omega-3 and CognitionA new study finds daily supplementation with Omega-3 essential fatty acids may improve measures of cognitive function like perceptual speed and memory.

86 people with mild cognitive impairment (MCI) were randomly assigned to receive a placebo (olive oil) or an Omega-3 supplement (EPA 720 mg DHA 480 mg) daily for 6 months.  The average mean age of the participants was 71 years of age. Significant improvements in scores on Basic Cognitive Aptitude Tests (BCAT), which measure cognitive function, were seen in the group taking the Omega-3 essential fatty acid supplements.  Additionally significant improvements in working memory, space imagery efficiency and perceptual speed were seen in the Omega-3 group while no improvements were seen in recognition memory or mental arithmetic efficiency.  Men tended to see significant improvements in space imagery efficiency, working memory, and perceptual speed, while women saw significant improvements in space imagery and perceptual speed.  Both men and women saw significant improvements in BCAT scores compared to the placebo group.

Because the study group was small further research is needed.

Make sure your fish oil is molecularly distilled to remove potential toxins.  Also a Fish oil that is manufactured to comply with strict European standards will be free of heavy metals, PCB’s, dioxins, pesticides and other unwanted compounds.  An enteric coating will protect the Fish Oil  from the harsh environment of the stomach, and then  the softgel will better travel to the small intestine where it can be digested and its fatty acids released and absorbed into the body. This prevents a fishy aftertaste and odor, and is helpful to sensitive individuals.  Some products will use lemon oil to help with the digestion of the Fish Oil softgel without any fishy burps.

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Vitamin C and E Supplements May Protect Against Age-Related Brain Declines

Cognitive DeclineData from a recent study shows daily supplementation with Vitamin C and Vitamin E could reduce the risk of cognitive decline.

Data from over 5,000 seniors collected over a period of time (from 1991-2002) was analyzed.  Participants were all over 65 years of age.  Seniors who were supplementing with Vitamin E and/or Vitamin C had a statistically significant 40% reduction in all cause-dementia and a 42% reduction in Alzheimer’s disease (AD).  Compared to non vitamin users, participants who were supplementing with either Vitamin C or Vitamin E separately saw a 43% and 46% reduction in the risks of developing Alzheimer’s disease.  Additionally, the risk of developing cognitive impairment not dementia (CIND), were reduced by 31% in the seniors who supplemented with Vitamin C and 32% for seniors who supplemented with Vitamin E.

As we age there is a natural decline in brain function.  Mild cognitive impairment is considered a transitional state and small changes in mental abilities and memory coexist with normal functioning.  These declines in functions may often be a warning sign of dementia.  Dementia is a term that is used to describe many different brain disorders that all share a progressive loss of brain function.  It is believed that Oxidative stress may be a contributing factor to this process.

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Resveratrol Shows Metabolic and Brain Signaling Benefits

ResveratrolA new animal study found that daily supplementation with Resveratrol may increase energy metabolism, cell signaling pathways and neurotransmission.

23 male adult monkeys were randomly assigned to one of three groups: A control group fed a healthy diet, A negative control group fed a diet high in sugar and fat and a group fed a diet high in sugar and fats and supplemental Resveratrol (80 mg per day for the first year and 480 mg per day for the second year).  The study lasted 2 years.  Researchers used proteomics to identify changes in the expression of 12 specific proteins in the brains of these rhesus monkeys.

Improvements in energy metabolism and the efficiency of cell signaling pathways and neurotransmission in the group supplementing with the Resveratrol in addition to the high fat and sugar diet were seen.

This study adds to the existing science on the healthy benefits of Resveratrol, a very powerful polyphenal.  A lot of research has focused on Resveratrol’s cardiovascular benefits due to the nutraceuticals association with the “French Paradox”.  This phrase was used to describe the low incidence of obesity and heart disease in the French people even though they have a diet moderately high in fat.  It is believed to be their consumption of Red wine that neutralizes the damage of their high fat diet.

Further studies are needed.

A good Resveratrol product will be standardized to 200 mg of trans-resveratrol (the phyto-nutrient in the resveratrol that gives the polyphenal its beneficial properties).  Additional Grape Seed Extract may be added to provide additional antioxidant benefits.

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