CO-Q10 Supplementation Improves Fatty Liver, Reduces Markers of Inflammation in NAFLD

CoQ10 and NAFLDA new randomized double blind trial of both men and women with NAFLD (Nonalcoholic fatty liver disease) found positive results for supplemental coenzyme Q10.  NAFLD describes a disease of the liver that is characterized by fat accumulation in the liver, enlargement of the liver and increased serum liver enzyme levels.  Increase inflammation also accompanies this disease.

41 individuals with mild to moderate NAFLD participated in this study.  20 people received a daily 100 mg dose of CoQ10 for 12 weeks.  The remainder of the participants received a placebo.  Both before and after the study period markers of inflammation (C-reactive protein and tumor necrosis factor), liver enzymes and NAFLD grade (percentage of liver cells with fat droplets) were measured.

Participants in the CoQ10 group showed reductions in inflammation markers in comparison with the placebo group as well as in comparison to their own CoQ10 group levels at the onset of the study.  In addition liver enzymes were lower at the end of the study compared to baseline in the CoQ10 group.  Improvements in the NAFLD grades were also seen in the CoQ10 group.

CoQ10 supplementation was seen as a good therapy for systemic inflammation reduction in addition to others therapies used to treat this disease.  Further studies are needed.

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Multi-Species Probiotics Affect Reaction to Sad Mood

Probiotics and SAD MoodA new study shows Probiotics significantly reduced cognitive reactivity to sad mood, which is a marker of vulnerability to depression and considered an important target for interventions.

20 healthy individuals with no current mood disorders participated in this 4 week triple-blind, placebo-controlled, randomized, pre-and post-intervention assessment designed study.  Participants in the study received either a placebo or a Multi Species Probiotic supplement.  The Probiotic supplement contained these species of friendly bacteria: Bifiodobacterium  bifidum, Bifidobacterium lactis, Lactobaciullus acidophilus, Lactobacillus brevis, Lactobacillus casei, Lactobacillus salivarius, and Lactococcus lactis.   Cognitive reactivity to sad mood was determined using the revised Leiden index of depression sensitivity scale in both the pre- and post-intervention assessment.

Participants receiving the Probiotic supplement showed a significant reduction in their overall cognitive reactivity to sad mood.  This was largely seen in a reduction of aggressive thoughts and a reduction in ruminations (deeply considered thoughts about things).

It is believed that the brain and the intestines are closely connected by the gut-brain axis.  This study shows communications occur due to interactions with intestinal microbiota signaling molecules which play a role in brain regulation and behavior.  This may explain the positive mood effects often seen by individuals supplementing with Probiotic supplements.

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Omega-3 and Moist Compresses Novel Approach to Dry Eyes

Omega3 and Dry EyeA new pilot study found a combination of supplementing with Omega-3 Essential Fatty Acids and a Warm Heat Compress can be an effective alternative option for treating Dry Eye Disease (DED).

35 individuals (33 of whom completed the study) participated in this 4 week trial.  Participants varied in age from 18 to 75 years of age and suffered from Meibomian Gland Disease (MGD), an ocular surface disease.

The Meibomian glands secrete a protein and lipid (fat) mixture in the eye.  This mixture creates a clear optical surface for the cornea and improves stability as well as reduces the tear film evaporation.  Additionally MGD prevents tear overflow and bacterial colonization.  When the gland is not functioning it destabilizes the tear film which causes increased evaporation. MGD is believed to be an instigator of DED.

In this study, participants supplemented with supplement that contained 810 mg of Omega-3 Essential Fatty Acids and used a warm eye compress heated for 30 seconds in the microwave and left on closed eyes for 5 minutes daily.

Over 54% of the study participants were considered to have Dry Eye Disease.  Participants showed a significant improvement between baseline and the end of the study period with 45% of the participants reporting they no longer had symptoms of DED.

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Folic Acid Supplements May Reduce Stroke Risk in Hypertensive Patients

Folic Acid and Stroke PreventionA new research team has suggested that supplementation with Folic Acid may reduce the risk of stroke by approximately 75% in individuals with High Blood Pressure.

Over 10,750 individuals who were a part of the China Stroke Primary Prevention Trial (CSPPT) participated in this RCT (randomized controlled trial).  Participants varied in age from 45 to 75 years of age.  All participants had Hypertension or were taking Anti-Hypertensive medication.  Participants were randomly assigned into two groups.  Group one contained over 5,400 patients who received either a daily 10 mg oral dose of Enalapril, an Anti-Hypertensive, plus 800 mcg of Folic Acid.  Group two contained over 5,300 patients who received only the Enalapril.

210 first strokes occurred in group two, the Enalapril only group, while 161 first strokes occurred in group one, the Enalapril plus Folic Acid group over a 4 year period.  Researchers determined that the risk of a first stroke was reduced from 5.6% to 1.8% in group one participants who shared low platelet counts and high homocysteine levels which represented a 73% risk reduction.  No benefits in Folic Acid supplementation was seen in participants with a high platelet count and low homocysteine levels.

Researchers concluded taking a B Vitamin or a Multi-Vitamin/Mineral Supplement containing Folic Acid was a wise move for all adults.

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Fighting Malnutrition:High-Dose Vitamin D Aids Weight Gain and Brain Development

Vitamin D and MalnutritionAccording to a new study supplementing with a high-dose of Vitamin D may improve language and motor skills development as well as improve weight gain in malnourished children.

185 severely malnourished children between the ages of 6 and 58 months provided the data for this trial.  All the participants were given high energy food sachets and were randomized to either receive a Vitamin D supplement or a placebo.  The study lasted 8 weeks.

The group who were receiving the supplement of Vitamin D experienced a significant improvement in weight (.26 kg compared to the control group).  Additionally Vitamin D seemed to considerably reduce the proportion of children experiencing delayed global development, delayed language development and delayed motor development, which were defined by reaching milestones like learning to talk or walk.

Throughout the world may children live with severe malnutrition which increases their risks of suffering from both physical and mental health conditions.  Currently only modest amounts of Vitamin D are included in the high energy food sachets, which are the typical protocol for the treatment of severe acute malnutrition.

Further studies are planned.

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Oily Fish, Vitamin B6 and Zinc May Delay Menopause

Menopause and Fish Oil, Vitamin B-6 and ZincNew research supports a later onset of natural menopause when there is a high intake of oily fish, Zinc and Vitamin B6.  The opposite seems to likely when the diet is high in refined carbohydrates.

Data from the UK Women’s Cohort Study (UKWCS), which had over 14,000 women participants, was used for this research.  A health study and a reproductive history were given.  A diet questionnaire was also filled out by all participants.  A follow up questionnaire and another survey were given to the participants after four years.  This allowed the researchers to determine that 900 women had experienced the beginnings of natural menopause.  The diets of these participants were then assessed.

Researchers found that in women whose diet’s included high amounts of oily fish, there was a delay in the beginning of their menopause by almost 3 years.  In women whose diet included high amounts of rice and refined pasta, their menopause was more like to begin a year and a half earlier than average.  Additionally the study found that an association also existed between the antioxidant properties of Vitamin B6 and Zinc and a later onset of natural menopause. Women who experience menopause earlier than average have a greater risk of future unhealthy conditions like heart disease and osteoporosis.

Further studies are needed to clarify how these findings may affect well being and health.

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Resveratrol’s Inflammatory Potential Boosts Bone Health in Obese Men

Resveratrol and Bone HealthA new study finds resveratrol may increase bone health in obese men, by supporting increased bone formation and mineralization.

74 men with an average age of 49 years old, participated in this double blind placebo controlled randomized study.  The mean body mass index (BMI) of participants was 33.7.  It seems that resveratrol activated a gene called sirtuin1 (Sirt1) and was effective in changing bone alkaline phosphatase (BAP).  BAP improved significantly over the 16 week study.

Resveratrol, a polyphenol, has been associated with benefits for cardiovascular health, blood sugar support and energy and endurance enhancements.  Resveratrol is the phytonutrient found in grapes and red wine.

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