What Impact Will Mid Life Vitamin D Levels Have on Cognitive Health 13 Years Later?

Vitamin D and Brain HealthA 13 year follow up study has found higher vitamin D levels in middle age may determine improvements in cognitive outcomes later in life.  This positive association applied only to participants with low educational levels.  Cognitive reserve, the idea used to explain why the same degrees of neuropathology or brain damage affects some people and not others, was used as the explanation of these study results. Over 1000 individuals who participated in the French “Supplementation en Vitamines et Mineraux Antioxydants” study were reviewed for this current study 13 years later.  Cognitive performance was taken by trained neuropsychologists.  A variety of tests were performed.  Because cognitive performance was not performed at the beginning of the original study it was not possible to track cognitive decline. Findings showed among participants with a secondary education only, there was no association between any cognitive variables and vitamin D levels.  The only exception to this was phonemic fluency.  In this area better outcomes were seen in participants with higher vitamin D levels.  Individuals with a low education showed that their vitamin D levels were most strongly associated with the performance of working memory. This reinforces previous results of other meta analysis. ASK US. WE KNOW. NOBODY KNOWS NUTRITION LIKE WE DO. NOBODY! http://naturesvitaminsonline.com http://earthwiseLF.com
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Metabolic Syndrome Patients Need More Vitamin C to Break Cycle of Antioxidant Depletion

etabolic Syndrome and Vitamin CResearchers say a higher intake of Vitamin C is necessary for metabolic syndrome patients trying to stop a potentially deadly cycle of health-related problems and antioxidant disruption.  35% of the adult population in the United States is believed to suffer from metabolic syndrome.

Saturated fat, which is high in many people’s diets here in the U.S., causes chronic low-grade inflammation in the body.  This chronic inflammation is believed to lead to the development of metabolic syndrome.  Metabolic syndrome is associated with dementia, cardiovascular disease, type 2 diabetes, cognitive dysfunction and fatty liver disease. A person with at least 3 of these conditions is considered to have metabolic syndrome: high triglyceride levels, low HDL cholesterol (good cholesterol), high blood sugar, high blood pressure and abdominal obesity.

It is believed that an imbalance in gut microbiomes caused by eating high amounts of saturated fats contributes to toxins in the bloodstream which in turn causes Vitamin C depletion and subsequently impairs Vitamin E benefits.  Antioxidants like Vitamin C and Vitamin E protects against oxidative stress caused by inflammation and free radicals, unstable molecules that harm the body’s cells.  Vitamin C is known to protect Vitamin E, so when you have lipid peroxidation (the process by which free radicals try to find a way to stabilize themselves by stealing electrons from cell membranes which causes damage to cells) Vitamin E gets used up and Vitamin C regenerates the Vitamin E.  Without Vitamin C, Vitamin E is lost and your body ends up in a vicious cycle of depleting the body’s natural antioxidants protections.

Injury to the gut occurs when there is too much fat in the diet.  Bacterial cell walls might begin to leak from the gut and begin circulating in the body causing neutrophils, the most abundant type of white blood cells, to chase them down.  Neutrophils attack bacteria and that destroys Vitamin C.  This process keeps repeating without intervention.  People with metabolic syndrome can have the same amount of Vitamin C in their diet as individuals without metabolic syndrome but they will have lower plasma concentrations of Vitamin C. So increases in supplementation or dietary intake are a must.

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Taking Vitamin C Prior to Workout May Have Recovery Benefits

Vitamin C and Exercise RecoveryA new study found women who supplemented with 1000 mg of Vitamin C (Ascorbic Acid) prior to a 30 minute moderate-intensity cycling session showed increases in antioxidant capacity after their exercise. 19 women between the ages of 22 and 25 participated in this research.  The participants in this study were sedentary for a least one year (did not participant in any regular exercise programs) to overcome any study bias that suggested “antioxidant supplementation only improved performance when endogenous levels are already depleted, and after reaching normal concentrations, no further benefit is seen”.  This conclusion was reached in a 2007 study published in The Journal of Nutritional Biochemistry.   Participants ingested one capsule of 1000 mg of Ascorbic Acid or a placebo for one exercise day.  Participants then went through a one week “wash-out” period before they returned to the lab took a different capsule, performed the same exercise and blood analysis protocol.  Blood samples were taken right before and right after exercise.  Additionally another blood sample was taken 30 minutes after exercise to determine muscle damage, oxidative stress, glucose, total protein and plasma albumin markers. Researchers found Superoxide Dismutase activity, a marker of stress in the body was elevated after exercise in participants who supplemented with the placebo but were suppressed in participants who supplemented the Vitamin C capsules.  Researchers concluded that supplementation with Vitamin C prior to exercise improved antioxidant power. A few limitations in the study design were seen, for example participants exercised in a fasted state and hence it was more difficult to extrapolate results seen to normal conditions when athletes were not fasting. Further studies are needed to completely understand how Vitamin C interacts with other molecules. ASK US. WE KNOW. NOBODY KNOWS NUTRITION LIKE WE DO. NOBODY! http://naturesvitaminsonline.com http://earthwiseLF.com

Deep Sleep Linked to Early Signs of Alzheimer’s Disease

Lack of Sleep and Alzheimer's DiseaseOne of the signs of Alzheimer’s disease (AD) is poor sleep; individuals with AD wake up exhausted and become less refreshed as their symptoms progress.  Until now it was not fully understood what this link was between restless nights and AD. New research has found that older individuals with less slow-wave sleep, the deep sleep needed to wake up feeling refreshed and to consolidate memories, have increased levels of tau, a brain protein.  Higher brain levels of tau are an indicator of Alzheimer’s disease as well as being linked to cognitive decline and brain damage.  These studies suggest poor sleep quality in later life might be a red flag for brain health deterioration. In this study over 115 individuals 60 years of age and older participated in this study.  Approximately 80% of these participants were considered to have normal cognition.  The balance of the participants experienced only mild cognitive impairment.  The participants sleep was monitored in their homes over a 7 day period.  A portable EEG monitor was placed on their foreheads to measure brain waves during sleep.  Additionally a wristwatch type sensor which tracked body movements was used.  Levels of tau protein and amyloid beta protein in the brain and cerebrospinal fluid were measure using PET brain scans or spinal taps.  Researchers after controlling for factors like movement during sleep, sex and age concluded higher levels of tau in the brain and higher tau-to-amyloid ratios in the spinal fluid was seen in participants with decreased levels of slow-wave sleep. It is the lack of quality sleep that may be the factor that determines AD risks. Alzheimer’s disease affects approximately 5.7 million Americans.  It appears that changes in the brain that lead to Alzheimer’s start silently and work slowly.  Amyloid beta protein may begin to form plaques in the brain up to 20 years prior to the classic AD symptoms, confusion and memory loss.  Tau protein tangles appear later which are then followed by atrophy of important brain areas.  This is when individuals begin to show the recognizable symptoms of cognitive decline.  The key would be to identify individuals who are at risk for developing AD prior to changes occurring in the brain interrupt their ability to think clearly.  It is now believed that sleep disturbances may be a good marker. ASK US. WE KNOW. NOBODY KNOWS NUTRITION LIKE WE DO. NOBODY! http://naturesvitaminsonline.com http://earthwiseLF.com

Endurance Exercise Maximizes Impact of Vitamins C and D on Metabolic Syndrome

Endurance Exercises-Vitamins-Metabolic SyndromeCurrent research shown while Vitamin C and Vitamin D can alleviate metabolic syndrome combing exercise with these supplements maximizes the impact to alleviate metabolic syndrome.

Over 150 individual’s ages between 30 to 50 years of age participated in the Randomized Controlled Trial.  Participants were assigned to one of six groups: Vitamin C group: participants took 500 mg of Vitamin C supplements daily.  Vitamin C plus PA: participants took the same dosage of Vitamin C at either 7:30 am or 3:00 pm and completed 30 minutes of daily endurance exercise.  Vitamin D group: participants took 2000IU of Vitamin D supplements daily in the morning.  Vitamin D plus PA: participants took the same dosage of Vitamin D at either 7:  amor 3:00 pm and completed 30 minutes of daily endurance exercise.  Placebo Groups: one group received a placebo and participated in 30 minutes of daily endurance exercise and the other group did not participate in the exercise but received the daily placebo supplement.  The study period lasted for 3 months and researchers collected data during this period.

Researchers found the Vitamin D had a larger influence on metabolic syndrome than the Vitamin C when evaluating the effects these supplements had on blood pressure, LDL cholesterol, total cholesterol and fasting plasma glucose levels.  The Vitamin C however was more effective for reducing HDL and triglyceride levels as well as waist circumference.  Individuals in the Vitamin D plus PA group showed lowered systolic blood pressure which was not seen in the Vitamin C group.

The main limitations of the study were its small sample size and short study period.

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Omega-3’s Don’t Increase Bleeding With Surgery

Omega-3 SurgeryIt has been the school of thought for many years that Fish Oils thinned the blood and that this blood thinning effect added to the risk for patients undergoing surgery especially for cardiac surgery patients where one of the dangers of cardiac surgery is uncontrolled fatal bleeding. In a secondary analysis of data from the OPERA study (Omega-3 fatty acids for the Prevention of postoperative Atrial Fibrillation) where over 1,500 patients scheduled for cardiac surgery participated, this idea was tested.  The treatment group was given large doses of Omega 3 Essential Fatty Acids (6.5 grams to 8 grams) for up to 5 days before surgery and then the treatment group received 1.7 grams of Omega 3 Essential Fatty Acids on the morning of surgery.  This maintenance dosage was continued until the participants were discharged from the hospital.  The participants who were not in the treatment group were given a placebo. When reviewing the data, researchers applied the criteria for bleeding put forth by BARC (Bleeding Academic Research Consortium).  Also the number of blood units need for transfusion was also reviewed. Researchers found the higher the blood levels of EPA and DHA (Omega-3 Essential Fatty Acids) was on the morning of surgery, the lower the risk for bleeding according the criteria from BARC.  Additionally there was a significant reduction in the number of units of blood needed for transfusions for patients in the treatment group. It is not understood exactly why researchers found lower risks in the group treated with Omega-3 Essential Fatty Acids since EPA has been shown to be an anticoagulant factor similar to the clotting inhabitation found with aspirin.  Researchers believe that the Anti-Inflammatory activity of Omega-3 may be playing an important role in the study results. ASK US. WE KNOW. NOBODY KNOWS NUTRITION LIKE WE DO. NOBODY! http://naturesvitaminsonline.com http://earthwiseLF.com

Data Supports Increased Role for Probiotics, Prebiotics in Healthy Aging

Probiotics and Healthy AgingGut dysbiosis (when the bacteria in the gut are out of balance) has commonly been associated with aging and the afflictions of aging.  Worldwide the implications of aging populations have become a major issue.

Alzheimer’s Disease:

4 bacterial strains common to all participants with Alzheimer’s Disease have been isolated in a recent study on Japanese Alzheimer’s Disease.  Studies also have shown reduced gut microbial diversity has been associated with this disease.

Osteoporosis:

Most of the microbiome data for this disease has come from mouse models.  A recent study has shown strains of Lactobacillus have been associated with increases in bone mass in addition to changes in the microbiota in the gut.  It has also been shown that prebiotics may actually increase Calcium absorption when taken together.

Sarcopenia, CVD Evidence:

There have been certain studies that link the prevention of muscle loss in mice with leukemia and probiotic supplementation.  Prebiotics have been shown to improve muscle function in humans when measuring grip strength.

Studies linking gut microbiome to both positive and negative roles in heart disease have been performed.  Certain aspects of gut dysbiosis have been linked with increased levels of trimethylamine-N-oxides in the liver which have been known to cause the formation of arterial plague.

Overall it is believed that the combination of lifestyle interventions that change the diversity or composition of gut microbiota, adequate exercise, and proper diet may be a key strategy in the maintenance of good health during the aging process.

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